AChE-IN-81

• Description:

  AChE-IN-81 (compound 22) is a potent, irreversible and selective AChE inhibitor. AChE-IN-81 inhibits activity on AChE with inhibitory rates of 80.0%, with an IC50 of 3.7 μM. AChE-IN-81 binds to AChE with a binding affinity (Kd) of 5.37 μM. AChE-IN-81 effectively reduces in zebrafish brain cells. AChE-IN-81 exhibits potential neuroprotective activities on H2O2-induced SH-SY5Y cell injury model[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Cholinesterase (ChE)

• Related Pathways:

  Apoptosis; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  ClC1=CC=CC=C1CNC([C@@]23CC[C@@]4(C)[C@]5(C)CC[C@@]6([H])[C@@](CO)(C)[C@@H](O)[C@H](O)C[C@]6(C)[C@@]5([H])CC=C4[C@@]([H])2[C@](C)(O)[C@H](C)CC3)=O

• Molecular Formula:

  C37H54ClNO5

• Molecular Weight:

  628.28

• References & Citations:

  [1]Zhang F, et al. Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD. Adv Sci (Weinh) . 2025 Feb 20:e2412903.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE