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SHP2-IN-35

CAT: 0804-HY-170877Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170877Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHP2-IN-35 (Compound 3f) is the inhibitor for SHP2. SHP2-IN-35 exhibits antiproliferative activity in cancer cells RKO, SW480 and CT26 with IC50 of 5.72 μM, 3.71 μM and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the cell cycle associated gene expressions, and induces mitochondrial-related autophagy. SHP2-IN-35 inhibits the expression of certain cytokines and chemokines in the tumor microenvironment (TME), thereby regulating the tumor progression[1].
UNSPSC
12352005
Target
Akt; Autophagy; PI3K; SHP2
Related Pathways
Autophagy; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(/C=C/C1=CC=C(OC)C(OC)=C1)/C(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)=C/c3cccc3.[][Fe][].c4cccc4
Molecular Formula
C34H32FeO6
Molecular Weight
592.46
References & Citations
[1]Zhang XZ, et al., Ferrocenyl-Substituted Curcumin Derivatives as Potential SHP-2 Inhibitors for Anticolorectal Cancer: Design, Synthesis and In Vitro Evaluation. ACS Omega. 2024 Dec 18;9 (52) :51701-51718.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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