SHP2-IN-35

CAT: 0931-T205173-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T205173-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Autophagy, Phosphatase, Akt, PI3K

Related Pathways

PI3K/Akt/mTOR signaling, Metabolism, Cytoskeletal Signaling, Autophagy

Bioactivity

SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy) . Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.

Molecular Formula

C34H32FeO6

Molecular Weight

592.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-170877	SHP2-IN-35
E8ET1611-80	SHP2
GTR18078133	SHP2 Antibody
BA8113-5	SHP2-IN-9
HY-176796	SHP2-IN-43
HY-145162-01	SHP2-D26
HY-155276	SHP2-IN-20
HY-155273	SHP2-IN-17
HY-175520	SHP2-IN-42
HY-172911-01	SHP2-IN-37

SHP2-IN-35

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