SHP2-IN-8

• Target:

  Others|||Phosphatase|||Apoptosis|||Akt

• Related Pathways:

  Cytoskeletal Signaling|||Metabolism|||Others|||Apoptosis|||PI3K/Akt/mTOR signaling

• Bioactivity:

  SHP2-IN-8 is a reversible, noncompetitive, selective and efficient allosteric SHP2 inhibitor (IC50=23 nM, Ki=22 nM), which also has effects in cells. SHP2-IN-8 can cause significant thermal displacement (? Tm = 7.01 ?) . SHP2-IN-8 can inhibit the phosphorylation of AKT and induce apoptosis of Hela cells.

• Smiles:

  NC=1N=C(N2CCC(CN)(C)CC2)C=NC1SC3=C(Cl)C(Cl)=CC=C3

• Molecular Formula:

  C17H21Cl2N5S

• Molecular Weight:

  398.35

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1801692-60-3