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SHP2-IN-29

CAT: 0804-HY-N12915Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N12915Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHP2-IN-29 (Compound 3) is a potent SHP2 inhibitor with an IC50 value of 0.18 μM. SHP2-IN-29 also has inhibitory activity against PTP1B and TCPTP, with IC50 values of 4.27 and 4.74 μM, respectively.
CAS Number
2130080-86-1
UNSPSC
12352005
Target
Phosphatase; SHP2
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/shp2-in-29.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=C(CC/C=C/C=C/CCC)C=C(O)C=C1O
Molecular Formula
C16H20O4
Molecular Weight
276.33
References & Citations
[1]Sun W, et al. Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships. Bioorg Med Chem Lett. 2017 Aug 1;27 (15) :3382-3385.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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