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RdRP-IN-9

CAT: 0804-HY-170649Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170649Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RdRP-IN-9 (Compound 6b) is a reversible covalent allosteric inhibitor of RdRp. RdRP-IN-9 demonstrates high anti-coronavirus activity, with an EC50 value of 0.68 μM against HCoV-OC43 RdRP-IN-9 exerts a more prolonged antiviral effect by reversibly acylating Cys12 in the NiRAN domain of non-structural protein 12 (nsp 12) and exhibits synergistic anti-coronavirus activity with Molnupiravir.
CAS Number
1101848-34-3
UNSPSC
12352005
Target
SARS-CoV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
[H][C@@]12[C@](C3=C[C@H](O)[C@H]2OC(CC)=O)([H])N(CC3)CC4=CC5=C(OCO5)C=C41
Molecular Formula
C19H21NO5
Molecular Weight
343.37
References & Citations
[1]Mei Y, et al. Lycorine esters exert anti-HCoV-OC43 effect through reversibly acylating cysteine residue in the nsp 12 NiRAN domain[J]. Bioorganic Chemistry, 2024: 108086.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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