RU-0415529

• Description :

  RU-0415529 is an orally active inhibitor for SARS-CoV-2 nonstructural protein 14 (NSP14) with an IC50 of 356 nM. RU-0415529 binds to the SAH-stabilized cap binding pocket, inhibits viral RNA methylation and the viral replication. RU-0415529 exhibits anti-infectious activity in mouse models[1].

• CAS Number :

  [1358734-35-6]

• UNSPSC :

  12352005

• Target :

  DNA Methyltransferase; SARS-CoV

• Related Pathways :

  Anti-infection; Epigenetics

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Smiles :

  CC1CCN(S(=O)(C2=C(C)N(C)C(C(NCC3=CC=CC=C3OC)=O)=C2)=O)CC1

• Molecular Formula :

  C21H29N3O4S

• Molecular Weight :

  419.54

• References & Citations :

  [1]Meyer C, et al., Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase. Nature. 2024 Dec 11.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported