RU 59063

• Description :

  RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom[1][2].

• CAS Number :

  [155180-53-3]

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Prostaglandin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/ru-59063.html

• Purity :

  98.61

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CC1=CC=C(C=C1C(F)(F)F)N(C2=O)C(N(C2(C)C)CCCCO)=S

• Molecular Formula :

  C17H18F3N3O2S

• Molecular Weight :

  385.40

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Teutsch G, et al. Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor. J Steroid Biochem Mol Biol. 1994 Jan;48 (1) :111-9.|[2]Van Dort ME, et al. Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3- (4-hydroxybutyl) -5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a high-affinity nonsteroidal androgen receptor ligand. J Med Chem. 2000 Aug 24;43 (17) :3344-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported