Ru-Poma

• Target:

  Ferroptosis|||Ligand for E3 Ligase

• Related Pathways:

  Apoptosis|||PROTAC

• Bioactivity:

  Ru-Poma is an Ru (II) -based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 ?M in the dark and 0.37 ?M under illumination.

• Molecular Formula:

  C89H75Cl2N11O11Ru.7H2O

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C