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Ru-Poma

CAT: 0931-T209925-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209925-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ferroptosis, Ligand for E3 Ligase
Related Pathways
Apoptosis, PROTAC
Bioactivity
Ru-Poma is an Ru (II) -based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.
Molecular Formula
C89H75Cl2N11O11Ru.7H2O
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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