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RU-39411

CAT: 0804-HY-117649Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117649Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RU-39411 is a steroidal anti-estrogen with mixed estrogenic/antiestrogen activity. RU-39411 has shown inhibitory effects on cell growth in the MCF-7 breast cancer model, with the effect being correlated with its binding affinity to the estrogen receptor. RU-39411 was able to downregulate the estrogen binding capacity of cells, but did not reduce estrogen receptor mRNA levels, indicating that the grafting of its side chain prevents the antagonistic effects usually associated with steroidal estrogens. The administration of RU-39411 can promote the synthesis of progesterone receptors, further supporting its activity as an estrogen[1].
CAS Number
120382-04-9
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ru-39411.html
Smiles
C[C@@]12[C@H](CC[C@]1([C@@]3(CCC4=C([C@]3([C@H](C2)C5=CC=C(C=C5)OCCN(C)C)[H])C=CC(O)=C4)[H])[H])O
Molecular Formula
C28H37NO3
Molecular Weight
435.60
References & Citations
[1]Antiestrogenic activity of two 11 beta-estradiol derivatives on MCF-7 breast cancer cells
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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