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Bfl-1-IN-6

CAT: 0804-HY-170434Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170434Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bfl-1-IN-6 (Compound 20) is an orally active inhibitor for Bcl-2 related protein A1 (BFL1) with an IC50 of 19 nM. Bfl-1-IN-6 stabilizes BFL1 protein, activates cleaved caspase 3, and exhibits antitumor efficacy in mouse models[1].
UNSPSC
12352005
Target
Bcl-2 Family; Caspase
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(N([C@@H](C)C1=CC=C(Cl)C=C1)C2=CC(F)=C(O[C@@H]3CC[C@@H](N)C3)C=C2)C=C
Molecular Formula
C22H24ClFN2O2
Molecular Weight
402.89
References & Citations
[1]Palisse A, et al., Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors. J Med Chem. 2024 Dec 26;67 (24) :22055-22079.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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