Bfl-1-IN-1

• UNSPSC Description:

  Bfl-1-IN-1 (Compound 15) is a potent and selective Bfl-1 inhibitor. Bfl-1-IN-1 inhibits Bfl-1 and Mcl-1 with Kis of 0.63 and 6.77 μM, respectively[1].

• Target Antigen:

  Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bfl-1-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(NC1=CC(SCC(O)=O)=C(OCC2CCCCC2)C3=CC=CC=C31)(C4=CC=C(C5=CC=CC=C5)C=C4)=O

• Molecular Weight:

  561.71

• References & Citations:

  [1]Niu P, et al. Discovery and optimization of (2-naphthylthio)acetic acid derivative as selective Bfl-1 inhibitor. Bioorg Med Chem Lett. 2024 Feb 18;101:129658.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported