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Bfl-1-IN-5

CAT: 0804-HY-169172-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169172-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bfl-1-IN-5 (Compound (R, R, S) -26) is a selective inhibitor for Bfl-1 with an IC50 of 0.022 μM. Bfl-1-IN-5 promotes the caspase-3/7 activity with an EC50 of 0.37 μM, and inhibits the cell viability of SU-DHL-1 with an EC50 of 1.3 μM[1].
UNSPSC
12352005
Target
Bcl-2 Family; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bfl-1-in-5.html
Smiles
C=CC(N(C1=CC=C(O[C@H]2C[C@H](N)CC2)C=C1)[C@H](C3=CC=C(C(F)(F)F)C(C#N)=C3)C)=O
Molecular Formula
C24H24F3N3O2
Molecular Weight
443.46
References & Citations
[1]Lucas SCC, et al., Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors. J Med Chem. 2024 Sep 26;67 (18) :16455-16479.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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