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Bfl-1-IN-6

CAT: 0931-T204150-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204150-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Bcl-2 Family, Caspase
Related Pathways
Proteases/Proteasome, Apoptosis
Bioactivity
Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.
Smiles
C[C@@H](C1=CC=C(C=C1)Cl)N(C2=CC(=C(C=C2)O[C@@H]3CC[C@H](C3)N)F)C(=O)C=C
Molecular Formula
C22H24ClFN2O2
Molecular Weight
402.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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