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CSF1R-IN-26

CAT: 0804-HY-168954Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168954Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSF1R-IN-26 (Compound III-1) is the inhibitor for CSF-1R with an IC50 of 20.07 nM. CSF1R-IN-26 promotes the polarization of M2 macrophages to M1 macrophages, thereby inducing apoptosis in MC-38 cancer cell. CSF1R-IN-26 inhibits the activation of AKT/ERK/STAT3 signaling pathway. CSF1R-IN-26 reconstructs the tumor immune microenvironment and exhibits antitumor activity in mouse models. CSF1R-IN-26 exhibits pharmacokinetics characteristics in SD rats with a half-life 1.86 hours, and an oral bioavailability of 79.22%[1].
UNSPSC
12352005
Target
Akt; Apoptosis; c-Fms; ERK; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
CC1=NC(NC(N[C@H]2[C@@H](CCCC2)O)=O)=CC=C1OC3=CNC4=C3C=C(C=N4)Cl
Molecular Formula
C20H22ClN5O3
Molecular Weight
415.87
References & Citations
[1]He J, et al., Discovery of Novel Pyrrolo[2,3-b]pyridine-Based CSF-1R Inhibitors with Demonstrated Efficacy against Patient-Derived Colorectal Cancer Organoids. J Med Chem. 2025 Mar 13;68 (5) :5655-5674.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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