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CSF1R-IN-26

CAT: 0013-GTR19258672-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258672-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.
CAS Number
3077238-23-1
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O (C=1C=2C (NC1) =NC=C (Cl) C2) C3=C (C) N=C (NC (N[C@H]4[C@H] (O) CCCC4) =O) C=C3
Molecular Formula
C20H22ClN5O3
Molecular Weight
415.87
Storage Conditions
-20°C
Notes
For research use only.

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