PAT1inh-B01 (hydrochloride)

• UNSPSC Description:

  PAT1inh-B01 hydrocholide is a selective SLC26A6 inhibitor. PAT1inh-B01 hydrocholide inhibits PAT1 (a Cl-/HCO3- exchanger)-mediated anion exchange (IC50: 350 nM). PAT1inh-B01 hydrocholide blocks fluid absorption in small intestine. PAT1inh-B01 hydrocholide can be used for research of small intestinal hyposecretory disorders[1].

• Target Antigen:

  Chloride Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pat1inh-b01-hydrocholide.html

• Solubility:

  DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C1C2=C(CCN(C2)C(CN3N=C(C(F)(F)F)C(Br)=C3C)=O)N=C4C=C(C5=CC=CC=C5)NN14.[H]Cl

• Molecular Weight:

  571.78

• References & Citations:

  [1]Cil O, et al. SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. JCI Insight. 2021 Jun 8;6(11):e147699.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported