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MAT2A-IN-21

CAT: 0804-HY-168445Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168445Size:1 Each
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Description
MAT2A-IN-21 (compound 28) is a potent methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 49 nM. MAT2A-IN-21 selectivity inhibits MTAP-deficient cancer cells[1].
CAS Number
3062073-94-0
UNSPSC
12352005
Target
Methionine Adenosyltransferase (MAT)
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C1C(C2=CC3=C(C=C2)N=CN3C)=NC4=CC=C(C=C4N1C5=CC=C(C=C5)OC(F)F)C6CC6
Molecular Formula
C26H20F2N4O2
Molecular Weight
458.46
References & Citations
[1]Li C, et al. Discovery of 2 (1H) -Quinoxalinone Derivatives as Potent and Selective MAT2A Inhibitors for the Treatment of MTAP-Deficient Cancers. J Med Chem. 2025 Jan 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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