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UBP 302

CAT: 0804-HY-107604-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107604-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UBP 302 is a potent and selective GLUK5-subunit containing kainate receptor antagonist (apparent Kd=402 nM), and displays very little affinity on GluK2 (GluR6) kainate receptors. Anxiolytic effects[1][2][3].
CAS Number
745055-91-8
UNSPSC
12352005
Hazard Statement
H302
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ubp-302.html
Concentration
10mM
Purity
99.75
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(N(C=CC1=O)C[C@H](N)C(O)=O)N1CC2=C(C=CC=C2)C(O)=O
Molecular Formula
C15H15N3O6
Molecular Weight
333.30
Precautions
H302
References & Citations
[1]More JC, et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47 (1) :46-64.|[2]Dolman NP, et al. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem. 2005 Dec 1;48 (24) :7867-81.|[3]Apland JP, et al. The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. J Pharmacol Exp Ther. 2014 Nov;351 (2) :359-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kainate Receptor

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