KP-302

• Description :

  KP-302 (Compound 23) is a selective inhibitor of protein arginine deaminase PAD2 with a Ki of 60 μM. KP-302 also reverses physical disability in the EAE mouse model of multiple sclerosis (MS) and eliminates T cell infiltration in the brain. KP-302 can be studied in research as a disease-modifying agent for MS[1][2].

• UNSPSC :

  12352005

• Target :

  Protein Arginine Deiminase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/kp-302.html

• Concentration :

  10mM

• Purity :

  99.78

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC=CN1C)N[C@H](C(NCC2=CC=CC=C2)=O)CCN3C=CN=C3

• Molecular Formula :

  C20H23N5O2

• Molecular Weight :

  365.43

• References & Citations :

  [1]Sarswat A, et al. Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis. Bioorg Med Chem. 2017 May 1;25 (9) :2643-2656.|[2]Caprariello, A. V., et al., (2018) . Biochemically altered myelin triggers autoimmune demyelination. Proceedings of the National Academy of Sciences of the United States of America, 115 (21), 5528–5533.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2082765-42-0]