AU-461

• Description :

  AU-461 is an orally active and reversible inhibitor of the gastric H⁺/K⁺ ATPase with IC₅₀ values for rabbit-derived and pig-derived enzymes are 12.15 μM and 4.20 μM respectively. AU-461 competes with activated cationic K⁺ (Kᵢ = 1.64 μM) . AU-461 reduces both histamine-stimulated gastric acid secretion and basal gastric acid secretion in rats. AU-461 inhibits ulcer formation caused by ethanol or sodium hydroxide, and restores the plasma gastrin level to normal. AU-461 can be used for the study of peptic ulcers[1].

• UNSPSC :

  12352005

• Target :

  Na+/K+ ATPase

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Metabolic Disease

• Smiles :

  CC1=C(N2C3=C(CC2)C(NCCO)=NC4=C3C=CC=C4OCC(F)(F)F)C=CC(OC)=C1

• Molecular Formula :

  C23H24F3N3O3

• Molecular Weight :

  447.45

• References & Citations :

  [1]Cheon HG, et al. Pharmacological properties of the gastric H (+) /K (+) ATPase inhibitor, AU-461. Pharmacology. 2000 Apr;60 (3) :161-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [220854-06-8]