AU-1421

• Description :

  AU-1421 is a potassium ion (K⁺) site-directed regulator that specifically acts on various cation transport ATPases. AU-1421 can distinguish between two different K⁺-sensitive phosphorylation intermediate (E2P) states: for non-K⁺ transport type ATPases (such as the sarcoplasmic reticulum Ca²⁺-ATPase), after binding to AU-1421, it mimics the agonistic effect of K⁺, significantly accelerating the hydrolysis (dephosphorylation) of E2P. For K⁺ transport type ATPases (such as the gastric mucosa H⁺/K⁺-ATPase and the renal Na⁺/K⁺-ATPase), after binding to AU-1421, it inhibits the hydrolysis of E2P, stabilizing the phosphorylated intermediate, thereby blocking the ion transport cycle. AU-1421 can be used to study the mechanism of the potassium ion pump[1].

• UNSPSC :

  12352005

• Target :

  Potassium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  CC(C=N1)=C(N2CCCCC2)C=C1/C=C\C3=CC=CC4=C3C=CC=C4.Cl

• Molecular Formula :

  C23H25ClN2

• Molecular Weight :

  364.91

• References & Citations :

  [1]Fukushima Y, et al. K (+) -site-directed pyridine derivative, AU-1421, activates hydrolysis of the K (+) -sensitive phosphoenzyme of sarcoplasmic reticulum Ca (2+) -ATPase and inactivates that of K (+) -transporting ATPases. Biochim Biophys Acta. 1992 Apr 29;1106 (1) :71-6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [115717-83-4]