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AU-1421

CAT: 0804-HY-165569Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-165569Size:1 Each
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Description
AU-1421 is a potassium ion (K⁺) site-directed regulator that specifically acts on various cation transport ATPases. AU-1421 can distinguish between two different K⁺-sensitive phosphorylation intermediate (E2P) states: for non-K⁺ transport type ATPases (such as the sarcoplasmic reticulum Ca²⁺-ATPase), after binding to AU-1421, it mimics the agonistic effect of K⁺, significantly accelerating the hydrolysis (dephosphorylation) of E2P. For K⁺ transport type ATPases (such as the gastric mucosa H⁺/K⁺-ATPase and the renal Na⁺/K⁺-ATPase), after binding to AU-1421, it inhibits the hydrolysis of E2P, stabilizing the phosphorylated intermediate, thereby blocking the ion transport cycle. AU-1421 can be used to study the mechanism of the potassium ion pump[1].
CAS Number
[115717-83-4]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC(C=N1)=C(N2CCCCC2)C=C1/C=C\C3=CC=CC4=C3C=CC=C4.Cl
Molecular Formula
C23H25ClN2
Molecular Weight
364.91
References & Citations
[1]Fukushima Y, et al. K (+) -site-directed pyridine derivative, AU-1421, activates hydrolysis of the K (+) -sensitive phosphoenzyme of sarcoplasmic reticulum Ca (2+) -ATPase and inactivates that of K (+) -transporting ATPases. Biochim Biophys Acta. 1992 Apr 29;1106 (1) :71-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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