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MYK-461

CAT: 0607-A8720-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0607-A8720-25Size:25 mg
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Description
inhibits adenosine triphosphatase activity
CAS Number
1642288-47-8
Product Name Alternative
(S)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione
Sequence
Mavacamten,SAR439152
Field of Research
Membrane Transporter Ion Channel ATPase
Purity
0.999
Form
A solid
Solubility
insoluble in H2O; ≥11.32 mg/mL in EtOH with ultrasonic; ≥13.65 mg/mL in DMSO
Smiles
C[C@H](NC(NC(N1C(C)C)=O)=CC1=O)C2=CC=CC=C2
Molecular Formula
C15H19N3O2
Molecular Weight
273.33
Shipping Conditions
Blue ice
Storage Conditions
Store at -20°C.

Chemical Information

Mavacamten

Mavacamten is a myosin inhibitor indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM). It received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used in humans. Mavacamten was also approved by Health Canada in October 2022 and by EMA in July 2023 for the same indication.

CAS Number1642288-47-8
PubChem CID117761397
IUPAC Name6-[[(1S)-1-phenylethyl]amino]-3-propan-2-yl-1H-pyrimidine-2,4-dione
Molecular FormulaC15H19N3O2
Molecular Weight273.33
XLogP2.1
Topological Polar Surface Area61.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity411
SMILES
C[C@@H](C1=CC=CC=C1)NC2=CC(=O)N(C(=O)N2)C(C)C
InChI
InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1
InChIKey
RLCLASQCAPXVLM-NSHDSACASA-N
Chemical Structure
2D Structure
2D structure of Mavacamten
CAS: 1642288-47-8
CID: 117761397
Formula: C15H19N3O2
MW: 273.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight273.33
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass273.147726857
Monoisotopic Mass273.147726857
Topological Polar Surface Area61.4 Ų
Heavy Atom Count20
Formal Charge0
Complexity411
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B3229-5MYK-461
S8861-10mM/1mLMavacamten (MYK-461)
C14563-10mM/1mLDanicamtiv (MYK-491)
HY-165498AU-461
T71244-01AM-461
HY-16620DF 461
MBS5775051DF-461

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