CP 461

• UNSPSC Description:

  CP-461 (OSI-461) is a selective apoptotic antineoplastic drug (SAAND) by engaging tubulin on colchicine site[1]

• Target Antigen:

  Apoptosis; Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cp-461.html

• Smiles:

  O=C(NCC1=CC=CC=C1)CC(C2=CC(F)=CC=C2/3)=C(C)C3=C\C4=CC=NC=C4.Cl

• Molecular Weight:

  420.91

• References & Citations:

  [1]Dong-Jun Fu, et al. Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization. Eur J Med Chem. 2018 Sep 5:157:50-61.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2

• CAS Number:

  227619-96-7