CP 461

• Description :

  CP-461 (OSI-461) is a selective apoptotic antineoplastic drug (SAAND) by engaging tubulin on colchicine site[1]

• Product Name Alternative :

  OSI-461

• UNSPSC :

  12352005

• Target :

  Apoptosis; Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cp-461.html

• Smiles :

  O=C(NCC1=CC=CC=C1)CC(C2=CC(F)=CC=C2/3)=C(C)C3=C\C4=CC=NC=C4.Cl

• Molecular Formula :

  C25H22ClFN2O

• Molecular Weight :

  420.91

• References & Citations :

  [1]Dong-Jun Fu, et al. Bioactive heterocycles containing a 3,4,5-trimethoxyphenyl fragment exerting potent antiproliferative activity through microtubule destabilization. Eur J Med Chem. 2018 Sep 5:157:50-61.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [227619-96-7]