SM-122

• Description:

  SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein (cIAP) -1/2. SM-122 can induce cIAP-1/2 degradation and weakly induce apoptosis in tumor cells. SM-122 can be used for the research of cancer, such as breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; IAP

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Smiles:

  O=C([C@H]1N2[C@](CCCC[C@@H](C2=O)NC([C@H](C)NC)=O)([H])CC1)NC(C3=CC=CC=C3)C4=CC=CC=C4

• Molecular Formula:

  C28H36N4O3

• Molecular Weight:

  476.61

• References & Citations:

  [1]Lu J, et al. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res. 2008 Nov 15;68 (22) :9384-93.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CIAP-1; cIAP-2

• CAS Number:

  874270-38-9