RGH-122

CAT: 0804-HY-162118Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-162118Size:1 Each
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Description
RGH-122 (compound 43) is an orally active, potent, selective, and hV1a receptor antagonist with Ki value of 0.3 nM and IC50 of 0.9 nM. RGH-122 showes microsomal stability with CLint value of 13/28/25 μL/min/mg[1].
CAS Number
[2355304-05-9]
UNSPSC
12352005
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rgh-122.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=[C@]2[N@]3C([C@H](CC4)CC[C@@H]4OC5=NC=CC=C5)=NN=C3CC6(OCCO6)CC2=C1
Molecular Formula
C24H25ClN4O3
Molecular Weight
452.93
References & Citations
[1]Baska F, et al. Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist. J Med Chem. 2024 Jan 11;67 (1) :643-673.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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