RTI-122

• UNSPSC Description:

  RTI-122 is a brain-penetrant and potent GPR88 agonist with good metabolic stability (half-life of 5.8 h in mice) and a cAMP EC50 of 11 nM. RTI-122 can be utilized in research on excessive drinking[1].

• Target Antigen:

  GPR88

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/rti-122.html

• Smiles:

  CO[C@H](C)[C@H](N)CN(C1=CC=C(C2=CC=C(C=C2)OC(C)C)C=C1)C([C@H]3[C@H](C4=CC=C(C=N4)F)C3)=O

• Molecular Weight:

  491.60

• References & Citations:

  [1]Rahman MT, et al. Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation. J Med Chem. 2023 Feb 23;66(4):2964-2978.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3034664-39-3