SM 10888

• Description:

  SM 10888 is a selective and orally active cholinesterase (ChE) inhibitor. SM 10888 can increase brain acetylcholine release. SM 10888 can be used for the research of neurological disease, such as Alzheimer's disease[1][2].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  NC1=C (C (F) =CC=C2) C2=NC3=C1CC4CC3C4.OC (C (O) =O) (CC (O) =O) CC (O) =O

• Molecular Formula:

  C20H21FN2O7

• Molecular Weight:

  420.39

• References & Citations:

  [1]Xu M, et al. Determination of basal acetylcholine release in vivo by rat brain dialysis with a U-shaped cannula: effect of SM-10888, a putative therapeutic drug for Alzheimer's disease. Neurosci Lett. 1991 Feb 25;123 (2) :179-82.|[2]Okazaki Y, et al. Effect of a novel CNS-selective cholinesterase inhibitor, SM-10888, on habituation and passive avoidance responses in mice. Jpn J Pharmacol. 1990 Jun;53 (2) :211-20.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  129297-21-8