MSX-122

• Description :

  MSX-122 is an orally active partial antagonist of CXCR4, inhibiting CXCR4/CXCL12 actions, with an IC50 of ～10 nM. MSX-122 has anti-inflammatory and anti-metastatic activity.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  CXCR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/MSX-122.html

• Purity :

  98.16

• Solubility :

  DMSO : 4 mg/mL (ultrasonic)

• Smiles :

  C1(CNC2=NC=CC=N2)=CC=C(CNC3=NC=CC=N3)C=C1

• Molecular Formula :

  C16H16N6

• Molecular Weight :

  292.34

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Liang Z, et al. Development of a unique small molecule modulator of CXCR4. PLoS One. 2012;7 (4) :e34038.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  CXCR4

• CAS Number :

  [897657-95-3]