AF-353 (Standard)

• Description:

  AF-353 (Standard) is the analytical standard of AF-353. This product is intended for research and analytical applications. AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].

• UNSPSC:

  12352100

• Target:

  P2X Receptor; Reference Standards

• Related Pathways:

  Membrane Transporter/Ion Channel; Others

• Field of Research:

  Cancer

• Smiles:

  CC(C)C1=C(OC2=CN=C(N)N=C2N)C=C(I)C(OC)=C1

• Molecular Formula:

  C14H17IN4O2

• Molecular Weight:

  400.21

• References & Citations:

  [1]Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160 (6) :1387-1398.|[2]Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110 (8 Pt B) :E409-414.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [865305-30-2]