ADH-353

• Description:

  ADH-353 can inhibit Aβ fibrillation and reduce Aβ-induced cytotoxicity in SH-SY5Y and N2a cells. ADH-353 can be used in Alzheimer's disease-related research[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/adh-353.html

• Smiles:

  O=C(C1=CC(NC(C2=CC(NC(C3=CC([N+]([O-])=O)=CN3CCCN)=O)=CN2CCCN)=O)=CN1CCCC)OCC

• Molecular Formula:

  C27H38N8O6

• Molecular Weight:

  570.64

• References & Citations:

  [1]Dabas A, et al. Structural Reorganization Mechanism of the Aβ42 Fibril Mediated by N-Substituted Oligopyrrolamide ADH-353. ACS Chem Neurosci. 2024 Sep 4;15 (17) :3136-3151.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2711712-81-9]