STF-1084

• Description :

  STF-1084 is a specific, cell-impermeable, competitive inhibitor of ENPP1 (Ki = 33 nM) . STF-1084 increases extracellular cGAMP concentrations by preventing its degradation by ENPP1, thereby enhancing immune infiltration. STF-1084 acts synergistically with ionizing radiation (IR) and cGAMP to delay tumor progression. STF-1084 can be used to study cancers with low immunogenicity[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H315, H318, H332, H335

• Target :

  Phosphodiesterase (PDE)

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  99.7

• Smiles :

  OP(O)(CCC1CCN(C2=C3C=C(OC)C(OC)=CC3=NC=N2)CC1)=O

• Molecular Formula :

  C17H24N3O5P

• Molecular Weight :

  381.36

• Precautions :

  H302, H312, H315, H318, H332, H335

• References & Citations :

  [1]Carozza JA, et al. Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity. Nat Cancer. 2020 Feb;1 (2) :184-196.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2298390-71-1]