STF-31

• Description :

  STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μM. STF-31 is also a NAMPT inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Autophagy; GLUT

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/STF-31.html

• Purity :

  99.79

• Solubility :

  DMSO : ≥ 34 mg/mL

• Smiles :

  O=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2

• Molecular Formula :

  C23H25N3O3S

• Molecular Weight :

  423.53

• Precautions :

  H302

• References & Citations :

  [1]Chan DA, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 2011 Aug 3;3 (94) :94ra70.|[2]Dedda CD, et al. Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses. International Journal of Molecular Sciences. 2019 Oct 8; 20 (19) :4962.|[3]Wang L, et al. Glucose transporter 1 critically controls microglial activation through facilitating glycolysis. Molecular Neurodegeneration, 2019 Jan 11; 14 (1) :2.|[4]Morioka S, et, al. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature. 2018 Nov;563 (7733) :714-718.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  GLUT1

• CAS Number :

  [724741-75-7]