STF-118804

CAT: 0804-HY-12808-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12808-01Size:5 mg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
STF-118804 is a highly specific NAMPT inhibitor. STF-118804 activates AMPK and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer[1][2].
CAS Number
[894187-61-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
AMPK; mTOR; NAMPT
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/STF-118804.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=CN=C1)C2=CC=C(C3=NC(CS(=O)(C4=CC=C(C)C=C4)=O)=C(C)O3)C=C2
Molecular Formula
C25H23N3O4S
Molecular Weight
461.54
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Matheny CJ, et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21;20 (11) :1352-63.|[2]Espindola-Netto JM, et al. Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer. Oncotarget. 2017 Jun 29;8 (49) :85054-85067.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Popular Products