STF-083010

• Description :

  STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.

• CAS Number :

  [307543-71-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  IRE1

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/STF-083010.html

• Purity :

  98.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=S(C1=CC=CS1)(/N=C/C2=C3C=CC=CC3=CC=C2O)=O

• Molecular Formula :

  C15H11NO3S2

• Molecular Weight :

  317.38

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Papandreou I, et al. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 2011 Jan 27;117 (4) :1311-4.|[2]Chien W, et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget. 2014 Jul 15;5 (13) :4881-94.|[3]Namba T, et al. Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway. Oncotarget. 2015 Aug 21;6 (24) :19990-20001.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported