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SB 258741

CAT: 0804-HY-136678Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-136678Size:1 Each
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Description
SB 258741 is an efficient and highly selective 5-HT7 receptor (pKi = 8.5) antagonist. SB 258741 can be used for research on neurological disorders such as schizophrenia and depression[1].
CAS Number
201038-58-6
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=S(N1[C@@H](CCN2CCC(C)CC2)CCC1)(C3=CC=CC(C)=C3)=O
Molecular Formula
C19H30N2O2S
Molecular Weight
350.52
References & Citations
[1]Pouzet B, et al. Effects of the 5-HT (7) receptor antagonist SB-258741 in animal models for schizophrenia. Pharmacol Biochem Behav. 2002 Apr;71 (4) :655-65. |[2]Mahé C, et al. Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. Eur J Pharmacol. 2004 Jul 14;495 (2-3) :97-102.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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