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(1R,9S) -Exatecan

CAT: 0804-HY-13631TSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13631TSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(1R,9S) -Exatecan (DX8951f) is the (1R,9S) stereoisomer of Exatecan. Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].
CAS Number
2231666-57-0
Product Name Alternative
(1R,9S) -DX8951f
UNSPSC
12352005
Target
ADC Payload; Drug Derivative; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
N[C@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62
Molecular Formula
C24H22FN3O4
Molecular Weight
435.45
References & Citations
[1]Liu, Haidong, et al. Linkers, drug linkers and conjugates thereof and methods of using the same. WO2024149345. 2024-08-07
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Topo I

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