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SBI-0087702

CAT: 0931-T204265-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204265-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
864431-36-7
Target
PKC
Related Pathways
Chromatin/Epigenetic, Cytoskeletal Signaling
Bioactivity
SBI-0087702 enhances the cytoplasmic localization of ATF2 in melanoma cells. Induced translocation of ATF2 by SBI-0087702 to the mitochondria results in the loss of mitochondrial membrane integrity, thereby increasing apoptosis. Additionally, SBI-0087702 inhibits the growth and motility of melanoma cells. It also suppresses the phosphorylation of ATF2 at the Thr52 site by PKCε.
Smiles
O(C1=CC=C(C=C1)CCNCC2=CC=C(OC)C=3C=CC=CC32)C
Molecular Formula
C21H23NO2
Molecular Weight
321.413
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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