SD-208 (Standard)

CAT: 0804-HY-13227R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13227R-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SD-208 (Standard) is the analytical standard of SD-208. This product is intended for research and analytical applications. SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, and > 100-fold selectivity over TGF-βRII.
CAS Number
[627536-09-8]
UNSPSC
12352100
Target
Reference Standards; TGF-β Receptor
Related Pathways
Others; TGF-beta/Smad
Field of Research
Cancer
Smiles
FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(NC4=CC=NC=C4)=N2
Molecular Formula
C17H10ClFN6
Molecular Weight
352.75
References & Citations
[1]Uhl M, et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004 Nov 1;64 (21) :7954-61.|[2]Ge R, et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res. 2006 Jul 15;12 (14 Pt 1) :4315-30.|[3]Sun Y, et al. Inhibition of intimal hyperplasia in murine aortic allografts by the oral administration of the transforming growth factor-beta receptor I kinase inhibitor SD-208. J Heart Lung Transplant. 2014 Jun;33 (6) :654-61.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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