SB-773812

• Description:

  SB-773812 is a moderate-affinity antagonist at dopamine receptor 2 (pKi=7.4) and a high-affinity antagonist at the dopamine receptor 3 (pKi=8.5) and at the serotonin 5-hydroxytryptamine receptors 2A (pKi=9.0), 2C (pKi=8.1), and 6 (pKi=8.1) . SB-773812 is promising for research of central nervous system disorders[1][2].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Dopamine Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  CN1CCC2=CC(OC)=C(S(=O)(C3=CC=C(OCC4=CC=C(Cl)C=C4)C=C3)=O)C=C2CC1

• Molecular Formula:

  C25H26ClNO4S

• Molecular Weight:

  472.00

• References & Citations:

  [1]Garg A, et al. Amit Garg A Mechanism Based Population Pharmacokinetic-Pharmacodynamic Model for Epoetin Alfa and Darbepoetin Alfa in Chronic Kidney Disease Patients[J]. Poster Abstracts PAGE 2010, 47.|[2]Catafau AM, et al. Contribution of SPECT measurements of D2 and 5-HT2A occupancy to the clinical development of the antipsychotic SB-773812. J Nucl Med. 2011 Apr;52 (4) :526-34.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT2 Receptor;5-HT6 Receptor; D2 Receptor; D3 Receptor

• CAS Number:

  [630407-66-8]