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Tat-βsyn-degron

CAT: 0804-HY-P10360Size: 1 EachDry Ice: NoHazardous: No
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Description
Tat-βsyn-degron is an α-synuclein knockdown peptide that effectively degrades α-synuclein protein via the proteasome pathway. Tat-βsyn-degron effectively reduces α-synuclein protein levels in primary rat cortical neuron cultures. In a Parkinson's mouse toxicity model, Tat-βsyn-degron can alleviate parkinsonian toxin-induced neuronal damage and movement disorders[1].
CAS Number
2816095-52-8
UNSPSC
12352209
Target
α-synuclein
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tat-βsyn-degron.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC(CNC([C@H](CO)NC([C@H](CCCCN)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O
Molecular Formula
C132H237N59O31
Molecular Weight
3146.67
References & Citations
[1]Jin JW, et al. Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Commun Biol. 2021 Feb 19;4 (1) :232.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
α-synuclein

Chemical Information

Tat-|Asyn-degron
CAS Number2816095-52-8
PubChem CID171361313
IUPAC Name2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetic acid
Molecular FormulaC132H237N59O31
Molecular Weight3146.7
XLogP-16.7
Topological Polar Surface Area1580
Hydrogen Bond Donor Count64
Hydrogen Bond Acceptor Count45
Rotatable Bond Count124
Heavy Atom Count222
Formal Charge0
Complexity6990
SMILES
C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N)O
InChI
InChI=1S/C132H237N59O31/c1-68(2)60-91(119(219)190-99(69(3)4)120(220)170-64-96(198)173-79(29-16-52-160-125(142)143)106(206)177-83(30-17-53-161-126(144)145)109(209)174-77(27-14-50-158-123(138)139)103(203)171-66-98(200)201)186-118(218)92(62-73-39-43-75(195)44-40-73)187-121(221)100(70(5)6)189-97(199)65-169-104(204)93(67-192)188-115(215)82(26-10-13-49-135)185-122(222)101(71(7)193)191-117(217)89(36-23-59-167-132(156)157)183-113(213)86(33-20-56-164-129(150)151)180-111(211)85(32-19-55-163-128(148)149)179-112(212)87(34-21-57-165-130(152)153)182-116(216)90(45-46-94(137)196)184-114(214)88(35-22-58-166-131(154)155)181-110(210)84(31-18-54-162-127(146)147)178-108(208)81(25-9-12-48-134)176-107(207)80(24-8-11-47-133)175-105(205)78(28-15-51-159-124(140)141)172-95(197)63-168-102(202)76(136)61-72-37-41-74(194)42-38-72/h37-44,68-71,76-93,99-101,192-195H,8-36,45-67,133-136H2,1-7H3,(H2,137,196)(H,168,202)(H,169,204)(H,170,220)(H,171,203)(H,172,197)(H,173,198)(H,174,209)(H,175,205)(H,176,207)(H,177,206)(H,178,208)(H,179,212)(H,180,211)(H,181,210)(H,182,216)(H,183,213)(H,184,214)(H,185,222)(H,186,218)(H,187,221)(H,188,215)(H,189,199)(H,190,219)(H,191,217)(H,200,201)(H4,138,139,158)(H4,140,141,159)(H4,142,143,160)(H4,144,145,161)(H4,146,147,162)(H4,148,149,163)(H4,150,151,164)(H4,152,153,165)(H4,154,155,166)(H4,156,157,167)/t71-,76+,77+,78+,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,99+,100+,101+/m1/s1
InChIKey
ZBFBAWXXBOQAHE-GQOYYCLQSA-N
Chemical Structure
2D Structure
2D structure of Tat-|Asyn-degron
CAS: 2816095-52-8
CID: 171361313
Formula: C132H237N59O31
MW: 3146.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight3146.7
XLogP3-16.7
Hydrogen Bond Donor Count64
Hydrogen Bond Acceptor Count45
Rotatable Bond Count124
Exact Mass3145.8816068
Monoisotopic Mass3144.8782520
Topological Polar Surface Area1580 Ų
Heavy Atom Count222
Formal Charge0
Complexity6990
Isotope Atom Count0
Defined Atom Stereocenter Count22
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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