Ucf-101 (Standard)

CAT: 0804-HY-125959R-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125959R-01Size:1 mg
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Description
Ucf-101 (Standard) is the analytical standard of Ucf-101. This product is intended for research and analytical applications. Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC50 of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC50>200 μM) . Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect[1][2][3].
CAS Number
[313649-08-0]
UNSPSC
12352100
Target
Apoptosis; Reference Standards
Related Pathways
Apoptosis; Others
Field of Research
Neurological Disease; Cardiovascular Disease
Smiles
O=C(/C(C(N1C2=CC=CC=C2)=O)=C/C3=CC=C(C4=C([N+]([O-])=O)C=CC=C4)O3)N(C5=CC=CC=C5)C1=S
Molecular Formula
C27H17N3O5S
Molecular Weight
495.51
References & Citations
[1]Cilenti L, et, al. Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. J Biol Chem. 2003 Mar 28;278 (13) :11489-94.|[2]Liu HR, et, al. Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Circulation. 2005 Jan 4;111 (1) :90-6.|[3]Li Y, et, al. Ucf-101 protects in vivoandin vitro models of PD against 6-hydroxydopamine toxicity by alleviating endoplasmic reticulum stress via the Wnt/β-catenin pathway. J Clin Neurosci. 2020 Jan;71:217-225.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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