MI-223

• Description :

  MI-223 is a Mcl-1 regulator (Kd = 160 nM) . MI-223 binds to the BH1 domain, blocking Mcl-1-stimulated homologous recombination DNA repair, thus sensitizing cancer cells to DNA replication agents. MI-223 can be used in research on cancers such as lung cancer[1].

• UNSPSC :

  12352005

• Target :

  Bcl-2 Family

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C1N(/N=C/C2=CC=CC(OCC)=C2O)C(C3=CC=CC=C3Cl)=NC4=C1C=CC=C4

• Molecular Formula :

  C23H18ClN3O3

• Molecular Weight :

  419.86

• References & Citations :

  [1]Chen G, et al. Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy. J Clin Invest. 2018 Jan 2;128 (1) :500-516.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [907166-59-0]