TP-110

CAT: 0804-HY-118522Size: 1 EachDry Ice: NoHazardous: No

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Description

TP-110 is a proteasome inhibitor. TP-110 specifically inhibits the protease-like activity of the 20S proteasome, but does not affect the trypsin-like or peptidyl-glutamyl peptide hydrolysis activity. TP-110 inhibits the NF-κB pathway, activates caspase-8, -9, and -3, and causes PARP cleavage, significantly reducing the levels of cIAP-1 and XIAP. TP-110 causes cell cycle arrest at the G2/M phase and promotes apoptosis of cancer cells. TP-110 can be used in cancer research of prostate cancer and multiple myeloma, etc[1][2].

CAS Number

688737-95-3

UNSPSC

12352005

Target

Apoptosis; Caspase; IAP; NF-κB; PARP; Proteasome

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC([C@@H](C(N)=O)N(C([C@H](CC1=CC=C(C=C1)OC)NC(CC2=C3C=CC=CC3=CC=C2)=O)=O)C(CC4=CC=C(C=C4)OC)C=O)C

Molecular Formula

C37H41N3O6

Molecular Weight

623.74

References & Citations

[1]Iijima M, Momose I, Ikeda D. TP-110, a new proteasome inhibitor, down-regulates IAPs in human multiple myeloma cells. Anticancer Res. 2009 Apr;29 (4) :977-85.|[2]Momose I, et al. A new proteasome inhibitor, TP-110, induces apoptosis in human prostate cancer PC-3 cells. Biosci Biotechnol Biochem. 2007 Apr;71 (4) :1036-43.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 3; Caspase 8; Caspase 9; cIAP-1; NF-κB; PARP; XIAP

Chemical Information

TP-110

CAS Number	688737-95-3
PubChem CID	11592579
IUPAC Name	(2S)-2-[[(2S)-3-(4-methoxyphenyl)-2-[(2-naphthalen-1-ylacetyl)amino]propanoyl]amino]-N-[1-(4-methoxyphenyl)-3-oxopropan-2-yl]-3-methylbutanamide
Molecular Formula	C37H41N3O6
Molecular Weight	623.7
XLogP	5.9
Topological Polar Surface Area	123
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	15
Heavy Atom Count	46
Formal Charge	0
Complexity	974

SMILES

CC(C)[C@@H](C(=O)NC(CC1=CC=C(C=C1)OC)C=O)NC(=O)[C@H](CC2=CC=C(C=C2)OC)NC(=O)CC3=CC=CC4=CC=CC=C43

InChI

InChI=1S/C37H41N3O6/c1-24(2)35(37(44)38-29(23-41)20-25-12-16-30(45-3)17-13-25)40-36(43)33(21-26-14-18-31(46-4)19-15-26)39-34(42)22-28-10-7-9-27-8-5-6-11-32(27)28/h5-19,23-24,29,33,35H,20-22H2,1-4H3,(H,38,44)(H,39,42)(H,40,43)/t29?,33-,35-/m0/s1

InChIKey

IJDYUMDIJFFMQQ-ROSKKCPQSA-N

Chemical Structure

2D Structure

CAS: 688737-95-3

CID: 11592579

Formula: C37H41N3O6

MW: 623.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	623.7
XLogP3	5.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	15
Exact Mass	623.29953604
Monoisotopic Mass	623.29953604
Topological Polar Surface Area	123 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	974
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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