TP-3654

CAT: 0804-HY-101126-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-101126-01Size:5 mg

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Description

TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively.

CAS Number

[1361951-15-6]

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/TP-3654.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(C)(C)[C@H]1CC[C@H](NC2=NN3C(C=C2)=NC=C3C4=CC=CC(C(F)(F)F)=C4)CC1

Molecular Formula

C22H25F3N4O

Molecular Weight

418.46

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Foulks JM, et al. A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas. Neoplasia. 2014 May;16 (5) :403-12.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

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