TP-808

CAT: 0804-HY-13952-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13952-01Size:10 mg
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Description
TP-808 is an intermediate used in tetracycline antibiotic synthesis with antimicrobial activity. TP-808 binds to the 30S ribosome subunit of the bacteria, preventing aminoacyl-trNA from entering the A site, thereby inhibiting the extension of the protein chain. TP-808 can be used in antibiotic drug development research[1].
CAS Number
[852821-06-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tp-808.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)(C)[Si](C)(C)O[C@]12[C@](CC=CC2=O)([H])[C@@H](C3=C(C(OCC4=CC=CC=C4)=NO3)C1=O)N(C)C
Molecular Formula
C26H34N2O5Si
Molecular Weight
482.64
Precautions
H302, H315, H319, H335
References & Citations
[1]Clark RB, et al. Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents. J Med Chem. 2013 Oct 24;56 (20) :8112-38.|[2]Zhang W Y, et al. Process research and development of TP-808: a key intermediate for the manufacture of synthetic tetracyclines[J]. Organic Process Research & Development, 2017, 21 (3) : 377-386.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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