TP-808

• Description :

  TP-808 is an intermediate used in tetracycline antibiotic synthesis with antimicrobial activity. TP-808 binds to the 30S ribosome subunit of the bacteria, preventing aminoacyl-trNA from entering the A site, thereby inhibiting the extension of the protein chain. TP-808 can be used in antibiotic drug development research[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/tp-808.html

• Concentration :

  10mM

• Purity :

  99.72

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CC(C)(C)[Si](C)(C)O[C@]12[C@](CC=CC2=O)([H])[C@@H](C3=C(C(OCC4=CC=CC=C4)=NO3)C1=O)N(C)C

• Molecular Formula :

  C26H34N2O5Si

• Molecular Weight :

  482.64

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Clark RB, et al. Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents. J Med Chem. 2013 Oct 24;56 (20) :8112-38.|[2]Zhang W Y, et al. Process research and development of TP-808: a key intermediate for the manufacture of synthetic tetracyclines[J]. Organic Process Research & Development, 2017, 21 (3) : 377-386.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [852821-06-8]