TP-808

• UNSPSC Description:

  TP-808 is an intermediate used in tetracycline antibiotic synthesis with antimicrobial activity. TP-808 binds to the 30S ribosome subunit of the bacteria, preventing aminoacyl-trNA from entering the A site, thereby inhibiting the extension of the protein chain. TP-808 can be used in antibiotic drug development research[1].

• Target Antigen:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/tp-808.html

• Smiles:

  CC(C)(C)[Si](C)(C)O[C@]12[C@](CC=CC2=O)([H])[C@@H](C3=C(C(OCC4=CC=CC=C4)=NO3)C1=O)N(C)C

• Molecular Weight:

  482.64

• References & Citations:

  [1]Clark RB, et al. Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents. J Med Chem. 2013 Oct 24;56(20):8112-38.|[2]Zhang W Y, et al. Process research and development of TP-808: a key intermediate for the manufacture of synthetic tetracyclines[J]. Organic Process Research & Development, 2017, 21(3): 377-386.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  852821-06-8