TP-040

• Description :

  TP-040 (O-GlcNAcase-IN-1), a chemical probe, is a potent and novel OGA inhibitor with an IC50 value of 46 nM.

• Product Name Alternative :

  O-GlcNAcase-IN-1

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335

• Target :

  OGA

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tp-040.html

• Purity :

  98.59

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC1CCN(C2=NC(NCC3=CN(C)C=N3)=NC=C2)CC1

• Molecular Formula :

  C15H22N6

• Molecular Weight :

  286.38

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

• References & Citations :

  [1]Tawada M, et al. Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization. J Med Chem. 2021 Jan 28;64 (2) :1103-1115.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2757254-99-0]