TP-040

• Product Name Alternative:

  O-GlcNAcase-IN-1

• UNSPSC Description:

  TP-040 (O-GlcNAcase-IN-1) is a potent and novel OGA inhibitor with an IC50 value of 46 nM.

• Target Antigen:

  OGA

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/tp-040.html

• Purity:

  98.59

• Solubility:

  DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  CC1CCN(C2=NC(NCC3=CN(C)C=N3)=NC=C2)CC1

• Molecular Weight:

  286.38

• References & Citations:

  [1]Tawada M, et al. Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization. J Med Chem. 2021 Jan 28;64(2):1103-1115.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  2757254-99-0