TP-040

• Description:

  TP-040 (O-GlcNAcase-IN-1), a chemical probe, is a potent and novel OGA inhibitor with an IC50 value of 46 nM.

• Product Name Alternative:

  O-GlcNAcase-IN-1

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H335

• Target:

  OGA

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/tp-040.html

• Purity:

  98.59

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CC1CCN (C2=NC (NCC3=CN (C) C=N3) =NC=C2) CC1

• Molecular Formula:

  C15H22N6

• Molecular Weight:

  286.38

• Precautions:

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

• References & Citations:

  [1]Tawada M, et al. Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization. J Med Chem. 2021 Jan 28;64 (2) :1103-1115.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2757254-99-0