TP-110

CAT: 0931-T68869-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T68869-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

688737-95-3

Target

Others

Related Pathways

Others

Bioactivity

TP-110 is a new proteasome inhibitor, which shows potent growth inhibition in various tumor cell lines. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. TP-110 reduced the intrinsic inhibitor of apoptosis proteins (IAPs), cIAP-1 and XIAP, that suppress executioner caspases.

Smiles

C(C(N[C@@H](CC1=CC=C(OC)C=C1)C(N[C@H](C(NC(CC2=CC=C(OC)C=C2)C=O)=O)C(C)C)=O)=O)C=3C4=C(C=CC3)C=CC=C4

Molecular Formula

C37H41N3O6

Molecular Weight

623.74

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

TP-110

CAS Number	688737-95-3
PubChem CID	11592579
IUPAC Name	(2S)-2-[[(2S)-3-(4-methoxyphenyl)-2-[(2-naphthalen-1-ylacetyl)amino]propanoyl]amino]-N-[1-(4-methoxyphenyl)-3-oxopropan-2-yl]-3-methylbutanamide
Molecular Formula	C37H41N3O6
Molecular Weight	623.7
XLogP	5.9
Topological Polar Surface Area	123
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	15
Heavy Atom Count	46
Formal Charge	0
Complexity	974

SMILES

CC(C)[C@@H](C(=O)NC(CC1=CC=C(C=C1)OC)C=O)NC(=O)[C@H](CC2=CC=C(C=C2)OC)NC(=O)CC3=CC=CC4=CC=CC=C43

InChI

InChI=1S/C37H41N3O6/c1-24(2)35(37(44)38-29(23-41)20-25-12-16-30(45-3)17-13-25)40-36(43)33(21-26-14-18-31(46-4)19-15-26)39-34(42)22-28-10-7-9-27-8-5-6-11-32(27)28/h5-19,23-24,29,33,35H,20-22H2,1-4H3,(H,38,44)(H,39,42)(H,40,43)/t29?,33-,35-/m0/s1

InChIKey

IJDYUMDIJFFMQQ-ROSKKCPQSA-N

Chemical Structure

2D Structure

CAS: 688737-95-3

CID: 11592579

Formula: C37H41N3O6

MW: 623.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	623.7
XLogP3	5.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	15
Exact Mass	623.29953604
Monoisotopic Mass	623.29953604
Topological Polar Surface Area	123 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	974
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-118522	TP-110
FID30620-01	TP 064
FT137729-01	TP 0903
HY-138561	EFdA-TP
HY-119127	TP-680
HY-114224	TP-271
HY-101857-01	TP-020
HY-143518-01	TP-16
HY-100517-01	TP-472
527505	TP-3654

TP-110

Chemical Information

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