YM-202074

• Description:

  YM-202074 is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models[1].

• UNSPSC:

  12352005

• Target:

  MGluR

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(N(C1CCCCC1)C)C2=CN3C4=C(C=CC(CN(CCOC)C)=C4)N=C3S2

• Molecular Formula:

  C22H30N4O2S

• Molecular Weight:

  414.56

• References & Citations:

  [1]Kohara A, et al. Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models. Brain Res. 2008 Jan 29; 1191:168-79.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR1

• CAS Number:

  299900-83-7