YM-202074

• Target:

  Others|||GluR

• Related Pathways:

  Others|||Neuroscience

• Bioactivity:

  YM-202074 is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. YM-202074 binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. It inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells) .

• Smiles:

  C(N(C)C1CCCCC1)(=O)C2=CN3C=4C(N=C3S2)=CC=C(CN(CCOC)C)C4

• Molecular Formula:

  C22H30N4O2S

• Molecular Weight:

  414.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  299900-83-7